Item Type | Name |
Concept
|
Adenine
|
Concept
|
Adenylate Kinase
|
Concept
|
Adenosine
|
Concept
|
Adenosine Diphosphate
|
Concept
|
Aged, 80 and over
|
Concept
|
Aldehyde Reductase
|
Concept
|
Adenosine Monophosphate
|
Concept
|
Adolescent
|
Concept
|
Acromegaly
|
Concept
|
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
|
Concept
|
Aged
|
Concept
|
Amino Acids
|
Concept
|
Blood Pressure
|
Concept
|
Amino Acid Sequence
|
Concept
|
Adenosine Triphosphate
|
Concept
|
Adult
|
Concept
|
Energy Intake
|
Concept
|
Cardiac Output
|
Concept
|
Calcitonin
|
Concept
|
Calpain
|
Concept
|
Androgens
|
Concept
|
Chromosomes, Human, Pair 2
|
Concept
|
Analysis of Variance
|
Concept
|
Arginine
|
Concept
|
Cyclosporins
|
Concept
|
B-Lymphocytes
|
Concept
|
Base Sequence
|
Concept
|
Dipeptides
|
Concept
|
Autoantibodies
|
Concept
|
Body Constitution
|
Concept
|
Body Weight
|
Concept
|
Cattle
|
Concept
|
Child
|
Concept
|
Bromodeoxyuridine
|
Concept
|
Carbachol
|
Concept
|
Chromans
|
Concept
|
Chromosomes, Human, Pair 12
|
Concept
|
Chromosomes, Human, Pair 7
|
Concept
|
Cognition Disorders
|
Concept
|
C-Peptide
|
Concept
|
Guinea Pigs
|
Concept
|
Creatinine
|
Concept
|
Corticotropin-Releasing Hormone
|
Concept
|
Chromosomes, Human, Pair 20
|
Concept
|
Diabetes Mellitus, Type 1
|
Concept
|
Hospitals, Teaching
|
Concept
|
Cross Reactions
|
Concept
|
Imidazoles
|
Concept
|
Diabetic Neuropathies
|
Concept
|
Drug Synergism
|
Concept
|
Duodenum
|
Concept
|
Diazoxide
|
Concept
|
Diet
|
Concept
|
Immunosuppressive Agents
|
Concept
|
Indians, North American
|
Concept
|
Insulin
|
Concept
|
Child, Preschool
|
Concept
|
Dogs
|
Concept
|
Hypothalamo-Hypophyseal System
|
Concept
|
Expert Testimony
|
Concept
|
Diet, Diabetic
|
Concept
|
Dantrolene
|
Concept
|
Disease Susceptibility
|
Concept
|
Eating
|
Concept
|
Follicle Stimulating Hormone
|
Concept
|
Insulin-Like Growth Factor II
|
Concept
|
Insulinoma
|
Concept
|
Microtubule-Associated Proteins
|
Concept
|
Panax
|
Concept
|
Glucagon
|
Concept
|
Glucokinase
|
Concept
|
Fasting
|
Concept
|
Diet, Reducing
|
Concept
|
Obesity
|
Concept
|
Obesity, Morbid
|
Concept
|
Gonadotropins
|
Concept
|
Pancreatic Hormones
|
Concept
|
Dose-Response Relationship, Drug
|
Concept
|
Hypoglycemic Agents
|
Concept
|
Liver Neoplasms
|
Concept
|
Insulin-Like Growth Factor I
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
Concept
|
Hexokinase
|
Concept
|
Hydrocortisone
|
Concept
|
Flow Cytometry
|
Concept
|
Fluorescent Antibody Technique
|
Concept
|
Infant
|
Concept
|
Gastric Inhibitory Polypeptide
|
Concept
|
International Cooperation
|
Concept
|
Adenoma, Islet Cell
|
Concept
|
Isoantibodies
|
Concept
|
Leucine
|
Concept
|
Keratins
|
Concept
|
Carcinoma, Hepatocellular
|
Concept
|
Mice, Transgenic
|
Concept
|
Pregnancy
|
Concept
|
Immunohistochemistry
|
Concept
|
Insulin Antibodies
|
Concept
|
Opportunistic Infections
|
Concept
|
Organ Size
|
Concept
|
Molecular Sequence Data
|
Concept
|
NADP
|
Concept
|
Glycogen
|
Concept
|
Pulse
|
Concept
|
Pancreatic Neoplasms
|
Concept
|
Mice, Inbred C57BL
|
Concept
|
Middle Aged
|
Concept
|
Random Allocation
|
Concept
|
Motor Neurons
|
Concept
|
Peptide Fragments
|
Concept
|
Ovarian Diseases
|
Concept
|
Ovary
|
Concept
|
Oxygen Consumption
|
Concept
|
Liver
|
Concept
|
Oligopeptides
|
Concept
|
Perfusion
|
Concept
|
Palmitates
|
Concept
|
Sex Characteristics
|
Concept
|
Phosphorylation
|
Concept
|
NAD
|
Concept
|
Neuropeptide Y
|
Concept
|
Osmolar Concentration
|
Concept
|
Oxazoles
|
Concept
|
Feeding Behavior
|
Concept
|
Portal System
|
Concept
|
Portal Vein
|
Concept
|
Proinsulin
|
Concept
|
Protein Processing, Post-Translational
|
Concept
|
Proto-Oncogene Proteins
|
Concept
|
Gastrins
|
Concept
|
Genetic Markers
|
Concept
|
Glucose Tolerance Test
|
Concept
|
Glycerolphosphate Dehydrogenase
|
Concept
|
Immunoassay
|
Concept
|
Regression Analysis
|
Concept
|
Guanine
|
Concept
|
Rats, Zucker
|
Concept
|
Receptor, Insulin
|
Concept
|
Risk Factors
|
Concept
|
Uterus
|
Concept
|
Pulsatile Flow
|
Concept
|
Insulin Resistance
|
Concept
|
Intestinal Absorption
|
Concept
|
Intestinal Mucosa
|
Concept
|
Intestine, Small
|
Concept
|
Somatostatin
|
Concept
|
Potassium Channels
|
Concept
|
Self Care
|
Concept
|
Secretin
|
Concept
|
Somatomedins
|
Concept
|
Starvation
|
Concept
|
Sweetening Agents
|
Concept
|
Swine
|
Concept
|
Heparin
|
Concept
|
Heterochromatin
|
Concept
|
Humans
|
Concept
|
Body Mass Index
|
Concept
|
Tomography, Emission-Computed
|
Concept
|
Protein Biosynthesis
|
Concept
|
Superoxides
|
Concept
|
Thionucleotides
|
Concept
|
Stroke Volume
|
Concept
|
Plasminogen Activator Inhibitor 1
|
Concept
|
Inulin
|
Concept
|
Trisaccharides
|
Concept
|
Thyroxine
|
Concept
|
Weight Loss
|
Concept
|
Risk Assessment
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
Concept
|
Caspases
|
Concept
|
Weaning
|
Concept
|
Up-Regulation
|
Concept
|
Glucose Clamp Technique
|
Concept
|
Metabolic Clearance Rate
|
Concept
|
Exercise
|
Concept
|
Mitochondria
|
Concept
|
Program Evaluation
|
Concept
|
Causality
|
Concept
|
Least-Squares Analysis
|
Concept
|
Rats, Sprague-Dawley
|
Concept
|
Rats, Wistar
|
Concept
|
Myocardium
|
Concept
|
In Situ Hybridization
|
Concept
|
Mice, Obese
|
Concept
|
Oligodeoxyribonucleotides
|
Concept
|
Point Mutation
|
Concept
|
Mice, Knockout
|
Concept
|
Oxidative Stress
|
Concept
|
Transplantation Conditioning
|
Concept
|
Muscle, Skeletal
|
Concept
|
Apoptosis Regulatory Proteins
|
Concept
|
Glucose Transporter Type 2
|
Concept
|
Hepatocyte Nuclear Factor 1-alpha
|
Concept
|
Clinical Chemistry Tests
|
Concept
|
Caspase 3
|
Concept
|
Oscillometry
|
Concept
|
Peroneal Nerve
|
Concept
|
Neurotensin
|
Concept
|
Reactive Oxygen Species
|
Concept
|
Government Regulation
|
Concept
|
Intercellular Signaling Peptides and Proteins
|
Concept
|
Carboxypeptidase H
|
Concept
|
Proteomics
|
Concept
|
bcl-2-Associated X Protein
|
Concept
|
Hepatocyte Nuclear Factor 1
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
Concept
|
Human Growth Hormone
|
Concept
|
Area Under Curve
|
Concept
|
Cholinergic Agonists
|
Concept
|
Amino Acid Substitution
|
Concept
|
Pancreatic Polypeptide
|
Concept
|
Oligonucleotide Array Sequence Analysis
|
Concept
|
Leptin
|
Concept
|
Acarbose
|
Concept
|
Potassium Channels, Inwardly Rectifying
|
Concept
|
bcl-X Protein
|
Concept
|
Plant Extracts
|
Concept
|
Polycystic Ovary Syndrome
|
Concept
|
Placebos
|
Concept
|
Pregnancy Trimester, Third
|
Concept
|
Pro-Opiomelanocortin
|
Concept
|
Proline
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Mice
|
Concept
|
Aryl Hydrocarbon Receptor Nuclear Translocator
|
Concept
|
Radioimmunoassay
|
Concept
|
Retinol-Binding Proteins, Plasma
|
Concept
|
Ryanodine
|
Concept
|
Sarcoplasmic Reticulum
|
Concept
|
Renin
|
Concept
|
Receptors, Leptin
|
Concept
|
Calcium-Calmodulin-Dependent Protein Kinase Type 2
|
Concept
|
Succinate Dehydrogenase
|
Concept
|
Thiazolidinediones
|
Concept
|
Uncertainty
|
Concept
|
Biomedical Research
|
Concept
|
Tissue Distribution
|
Concept
|
Proprotein Convertase 1
|
Concept
|
Glucagon-Secreting Cells
|
Concept
|
Rats
|
Concept
|
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
|
Concept
|
TCF Transcription Factors
|
Concept
|
ADP-ribosyl Cyclase 1
|
Concept
|
Immunoprecipitation
|
Concept
|
Sex Factors
|
Concept
|
Growth Hormone
|
Concept
|
Streptozocin
|
Concept
|
Insulin-Secreting Cells
|
Concept
|
Sugar Alcohol Dehydrogenases
|
Concept
|
Blotting, Western
|
Concept
|
Hepatocyte Nuclear Factor 4
|
Concept
|
Pancreas Transplantation
|
Concept
|
Lentivirus
|
Concept
|
Thiazoles
|
Concept
|
Workload
|
Concept
|
Cyclosporine
|
Concept
|
Blotting, Southern
|
Concept
|
Reproducibility of Results
|
Concept
|
Skin Transplantation
|
Concept
|
Polymerase Chain Reaction
|
Concept
|
Antisense Elements (Genetics)
|
Concept
|
Leuprolide
|
Concept
|
Calcium-Calmodulin-Dependent Protein Kinases
|
Concept
|
Receptors, Neurotensin
|
Concept
|
ADP-ribosyl Cyclase
|
Concept
|
Tumor Suppressor Proteins
|
Concept
|
Bariatric Surgery
|
Concept
|
Transcription Factor 7-Like 2 Protein
|
Concept
|
Hepatocyte Nuclear Factor 1-beta
|
Concept
|
Hepatocyte Nuclear Factor 6
|
Concept
|
Basic Helix-Loop-Helix Transcription Factors
|
Concept
|
Somatostatin-28
|
Concept
|
KATP Channels
|
Concept
|
AMP-Activated Protein Kinases
|
Concept
|
Insulin Receptor Substrate Proteins
|
Concept
|
RNA, Small Interfering
|
Concept
|
Incretins
|
Concept
|
Antibodies
|
Concept
|
Blood Chemical Analysis
|
Concept
|
Body Surface Area
|
Concept
|
Calcium-Binding Proteins
|
Concept
|
Epinephrine
|
Concept
|
Ethidium
|
Concept
|
Factor V
|
Concept
|
Heart Rate
|
Concept
|
Injections, Subcutaneous
|
Concept
|
Jejunum
|
Concept
|
Mice, Mutant Strains
|
Concept
|
Mothers
|
Concept
|
Norepinephrine
|
Concept
|
Organ Specificity
|
Concept
|
Papio
|
Concept
|
Peptides
|
Concept
|
Personnel Staffing and Scheduling
|
Concept
|
Phenotype
|
Concept
|
Pituitary Neoplasms
|
Concept
|
Predictive Value of Tests
|
Concept
|
Pregnancy, Animal
|
Concept
|
Rats, Mutant Strains
|
Concept
|
Reaction Time
|
Concept
|
Vitamin A
|
Concept
|
Restriction Mapping
|
Concept
|
Gastric Bypass
|
Concept
|
Mice, Inbred NOD
|
Concept
|
Mexican Americans
|
Concept
|
DNA Primers
|
Concept
|
Receptors, Aryl Hydrocarbon
|
Concept
|
Genetic Predisposition to Disease
|
Concept
|
Imidazolidines
|
Concept
|
Overweight
|
Concept
|
bcl-2 Homologous Antagonist-Killer Protein
|
Concept
|
Proto-Oncogene Proteins c-akt
|
Concept
|
Glucose Transporter Type 4
|
Concept
|
Membrane Potential, Mitochondrial
|
Concept
|
Young Adult
|
Concept
|
Purinergic P2 Receptor Agonists
|
Academic Article
|
Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats.
|
Academic Article
|
Defects in beta-cell function in functional ovarian hyperandrogenism.
|
Academic Article
|
Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
|
Academic Article
|
NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.
|
Academic Article
|
Oscillatory insulin secretion after pancreas transplant.
|
Academic Article
|
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
|
Academic Article
|
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
|
Academic Article
|
Maturity onset diabetes of the young (MODY).
|
Academic Article
|
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
|
Academic Article
|
Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.
|
Academic Article
|
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
|
Academic Article
|
Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance.
|
Academic Article
|
Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients.
|
Academic Article
|
Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.
|
Academic Article
|
Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.
|
Academic Article
|
Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
|
Academic Article
|
Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance.
|
Academic Article
|
Diabetes mellitus and genetically programmed defects in beta-cell function.
|
Academic Article
|
Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
|
Academic Article
|
Ginseng berry reduces blood glucose and body weight in db/db mice.
|
Academic Article
|
Increased islet apoptosis in Pdx1+/- mice.
|
Academic Article
|
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
|
Academic Article
|
C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.
|
Academic Article
|
Visualizing superoxide production in normal and diabetic rat islets of Langerhans.
|
Academic Article
|
Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus.
|
Academic Article
|
The effect of a time delay on the characteristics of the canine glucoregulatory system.
|
Academic Article
|
Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites.
|
Academic Article
|
Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
|
Academic Article
|
Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic ß cell death and diabetes.
|
Academic Article
|
Insulin signaling in alpha cells modulates glucagon secretion in vivo.
|
Academic Article
|
Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus.
|
Academic Article
|
Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.
|
Academic Article
|
Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.
|
Academic Article
|
Introduction of Arthur H. Rubenstein.
|
Academic Article
|
Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.
|
Academic Article
|
Ingestion of a mixed meal does not affect the metabolic clearance rate of biosynthetic human C-peptide.
|
Academic Article
|
Insulin and glucagon breakthrough of somatostatin suppression: importance of portal vein hormone measurements.
|
Academic Article
|
The in vivo metabolism of somatostatin 28: possible relationship between diminished metabolism and enhanced biological action.
|
Academic Article
|
Evidence for the presence of somatostatin 28 in plasma.
|
Academic Article
|
Plasma somatostatin 28 increases in response to feeding in man.
|
Academic Article
|
Responses of somatostatin components to oral glucose in human plasma.
|
Academic Article
|
Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes.
|
Academic Article
|
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
|
Academic Article
|
The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes.
|
Academic Article
|
The effects of biosynthetic human proinsulin on carbohydrate metabolism.
|
Academic Article
|
Aldose reductase inhibition improves nerve conduction velocity in diabetic patients.
|
Academic Article
|
Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration.
|
Academic Article
|
Defects in insulin secretion and action in women with a history of gestational diabetes.
|
Academic Article
|
A new method for comparing portal and peripheral venous insulin delivery in humans: tolbutamide versus insulin infusion.
|
Academic Article
|
A familial glucagonoma syndrome: genetic, clinical and biochemical features.
|
Academic Article
|
Insulin secretion and clearance. Comparison after oral and intravenous glucose.
|
Academic Article
|
Calculation of the systemic delivery rate of insulin in normal man.
|
Academic Article
|
Variable deterioration in cortical function during insulin-induced hypoglycemia.
|
Academic Article
|
Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism.
|
Academic Article
|
Hepatic and renal metabolism of somatostatin-like immunoreactivity. Simultaneous assessment in the dog.
|
Academic Article
|
Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
|
Academic Article
|
Pancreatic hormone profiles and metabolism posthepatectomy in the dog. Evidence for a hepatotrophic role of insulin, glucagon, and pancreatic polypeptide.
|
Academic Article
|
Differential immunoreactivity of plasma glucagon components in man: studies with different glucagon antibodies.
|
Academic Article
|
Surface receptors for pancreatic hormones in dog and rat hepatocytes: qualitative and quantitative differences in hormone-target cell interactions.
|
Academic Article
|
C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.
|
Academic Article
|
Oscillations in insulin secretion during constant glucose infusion in normal man: relationship to changes in plasma glucose.
|
Academic Article
|
Predominance of renal and absence of hepatic metabolism of pancreatic polypeptide in the dog.
|
Academic Article
|
Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
|
Academic Article
|
Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited.
|
Academic Article
|
Lack of glucagon response to hypoglycemia in type I diabetics after long-term optimal therapy with a continuous subcutaneous insulin infusion pump.
|
Academic Article
|
Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.
|
Academic Article
|
The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes.
|
Academic Article
|
Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.
|
Academic Article
|
Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.
|
Academic Article
|
Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome.
|
Academic Article
|
Glucose counterregulation in patients after pancreatectomy. Comparison with other clinical forms of diabetes.
|
Academic Article
|
Relation of counterregulatory responses to hypoglycemia in type I diabetics.
|
Academic Article
|
Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research.
|
Academic Article
|
Heparin-induced lipolysis in hypertriglyceridemic subjects results in the formation of atypical HDL particles.
|
Academic Article
|
Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus.
|
Academic Article
|
Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
|
Academic Article
|
Organ alchemy: producing insulin in the liver.
|
Academic Article
|
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
|
Academic Article
|
Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.
|
Academic Article
|
Serum leptin levels in obese males during over- and underfeeding.
|
Academic Article
|
Effects of aging on insulin secretion.
|
Academic Article
|
Oxygen uptake kinetics during exercise in diabetic neuropathy.
|
Academic Article
|
C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations.
|
Academic Article
|
Glucose ingestion in dogs alters the hepatic extraction of insulin. In vivo evidence for a relationship between biologic action and extraction of insulin.
|
Academic Article
|
Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
|
Academic Article
|
Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
|
Academic Article
|
Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
|
Academic Article
|
Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.
|
Academic Article
|
BH3-only molecule Bim mediates ß-cell death in IRS2 deficiency.
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Academic Article
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Phase-locking regions in a forced model of slow insulin and glucose oscillations.
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Concept
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Uncoupling Protein 2
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Concept
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Beclin-1
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Concept
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Bcl-2-Like Protein 11
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Concept
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Sulfonylurea Receptors
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Concept
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Betacellulin
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